Symbol
Name
ID

Edn1
endothelin 1
MGI:95283

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Premature coronary artery atherosclerosis	Vasculitis	Hypertension	Sudden cardiac death	Myocardial infarction
Disease(s) Associated with EDN1	Premature coronary artery atherosclerosis	Vasculitis	Hypertension	Sudden cardiac death	Myocardial infarction
coronary artery disease
rheumatoid arthritis

Mouse Phenotypes

cardiovascular system phenotype

abnormal cardiovascular system morphology

abnormal pharyngeal arch artery morphology

abnormal fourth pharyngeal arch artery morphology

abnormal aorta morphology

aorta tubular hypoplasia

interrupted aorta

abnormal carotid artery morphology

absent right subclavian artery

double outlet right ventricle

overriding aortic valve

ventricular septal defect

dilated heart right ventricle

decreased response of heart to induced stress

decreased mean systemic arterial blood pressure

decreased systemic arterial diastolic blood pressure

decreased systemic arterial systolic blood pressure

increased systemic arterial blood pressure

hypertension

salt-sensitive hypertension

increased mean systemic arterial blood pressure

increased systemic arterial systolic blood pressure

Availability

Mouse Genotype

Edn1^tm1.1Ywa/Edn1^tm1.1Ywa

Edn1^tm1Utj/Edn1^tm1Utj

Edn1^tm1.1Ywa/Edn1⁺

Edn1^tm1Utj/Edn1⁺

Edn1^tm1Ywa/Edn1^tm1Ywa
Tg(Myh6-cre)2182Mds/0 (conditional)

Edn1^tm1Ywa/Edn1^tm1Ywa
Tg(AQP2-cre)2Dek/0 (conditional)

Edn1^tm1Ywa/Edn1^tm1Ywa
Tg(Tek-cre)1Ywa/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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